Nagging on non-existant drive

Once had an external drive (or camera??) on S:\
Now for no obvious reason W7 tries to access it and tries that every 5 secs, which makes the computer almost inoperable.
When it happens I found it in My Computer, but trying to remove it fails.
Only a restart helps.
Then I checked Management but it wasn't there on startup.
Tried to note WHEN it happens..but that's so difficult.

All help appreciated!

Try this.

Download v 0.8.1 of the drivecleanup.zip from Drive Tools for Windows.

Unzip it to a folder, say drivecleanup.

You will have two folders Win32 and x64 each containing DriveCleanup.exe for 32 bit and 64 bit respectively.

Remove all USB storage devices from your system (except your Keyboard and mouse) and reboot.

Right click on the DriveCleanup.exe and run as administrator. (Use the *.exe file appropriate for your bit version of Windows.).

After the clean up act, reboot and check whether your system is still asking for the non-existent drive.

( When you plug in your USB devices after this cleanup these will be installed afresh. What you have done is to remove all non-present devices and drive letters associated with them and start with a clean slate. Hopefully that should resolve the problem.)

Ran the program, after restart haven't seen the issue since.
Keeping my fingers crossed here!