I get your point.. it's a bit risky.. now I can compare it to an antibiotic.. it kills bacteria.. even the good one.. same with the combo fix.. it may delete the virus.. even your core files..
in my situation where I find CF useful.. I have a cousin who watch porn every night.. and when I use my computer I suddenly notice that its already infected(trojans,worms,backdoor). I install avira, AVG and other free antivirus software.. I also install malwarebye and ccleaner.. still no luck.. I entered the darkside (ifyouknowwhatImean).. it might work because it's a full version.. but STILL no LUCK!!.. so my last resort is to reformat my computer.. but I misplace my windows 7 DVD.. and using a pirated one is a bit hassle because I paid for my OS.. and at last... someone suggest to use CF.. it's like a do or die situation... and im really really impress because it fix my computer... the end