Pertaining the bios settings once they are set up you shouldn't have to touch them again. Make that a part of your set up and deployment process and you should be good however you will always need a hands and eyes team in an enterprise environment especially if there is an outage or hardware problems. There isn't any other way around it.
Well, I guess that's a "make sure you do it right the first time" suggestion. Agreed. Remote PCs in a scientific and reconnaissance environment often don't have the luxury of a hands- and eyes- team that an enterprise environment might, though.