All Start-up Applications Crash Even in Safe Mode

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urbansprinterco

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I have a Windows 7 x64 Gateway and recently my laptop froze completely, for 20 minutes, until I finally powered it down. Upon restarting, I found that all of my on-start applications had crashed and I was unable to access any files, desktop icons, or even the windows key/Start. The problem persisted as I relaunched in Safe Mode, with Windows Explorer sending constant crash reports and an unresponsive windows toolbar, without which I could not attempt a 'System Restore'. Any help is appreciated as I am running out of patience and know little about troubleshooting such issues.
 
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My Computer My Computer

At a glance

Windows 7 Home Premium x644 GB400 GB
Computer type
Laptop
Computer Manufacturer/Model Number
Gateway
OS
Windows 7 Home Premium x64
CPU
4 GB
Memory
400 GB
Okay....there's a need for more system spec details. What model of laptop...etc.
 

My Computer My Computer

At a glance

Microsoft Windows 10 Home Build 15036Intel(R) Core(TM) i7-860 @ 2.80GHz4.00 GBNVIDIA GeForce GTX 750
Computer type
PC/Desktop
Computer Manufacturer/Model Number
iBuyPower NZXT
OS
Microsoft Windows 10 Home Build 15036
CPU
Intel(R) Core(TM) i7-860 @ 2.80GHz
Motherboard
Gigabyte Technology Co., Ltd. P55-UD3L
Memory
4.00 GB
Graphics Card(s)
NVIDIA GeForce GTX 750
Sound Card
(1) Line 6 UX2 (2) Realtek High Definition Audio
Monitor(s) Displays
23" acer
Screen Resolution
1920 x 1080 x 32 bits (4294967296 colors) @ 60 Hz
Hard Drives
(1) WDC WD5000AAKS-00D2B0 ATA Device (2) Seagate FreeAgent Go 250G USB Device
Cooling
Corsair H75 liquid cooler (Very easy to install, actually)
Internet Speed
60M cable modem-->Linksys E1200-->1Gbps net card
Browser
Chrome
Other Info
This is probably the longest I've ever had a Windows machine run without having to restore it to scratch. I'm used to restoring to "factory" about every 2 yrs. I've run with Win7 since new in 2009 and only recently (Nov, '14) restored to clean up the machine from all my 'xperimenting. LOL!! I may never need another machine.

Upgraded to 10 when it was still free, then installed 2017 update.
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