Acronis TIH 2010 has a cloning utility that is found under the "Tools & Utilities" menu in the program. It can clone to any size disk, provided the data on the source disk will fit on the target disk. It has two modes, automatic and manual. If one uses automatic, then the partitions on the source will be automatically resized proportionally on the target if the target drive is a different size than the source. So if the target drive is larger than the source, each partition on the target will be automatically proportionally resized to be larger than they are on the source. This may or may not be desirable and this could make cloning not possible in some circumstances, depending on the size of the source partitions and the size of the target drive, if the target drive is smaller than the source.
So in the situation where the automatic mode produces undesirable results or won't work at all, one can use the manual cloning mode and this allows one to manually set the size of the partitions for the target drive, and use any size drive, again, assuming the data on the source partitions will actually fit on the target drive and in the partition sizes that one manually specifies.
So in sum, I have found Acronis TIH to quite easily make very reliable clones to any size drive, assuming there is sufficient space on the target drive to fit all the data that is on the source drive.
That said, for backing up my laptop drive by cloning (which I occasionally do in addition to regularly making compressed image backups), I usually clone to a drive that is the same size so I can use the automatic mode with just a few quick clicks, without having to manually resize any partitions. It just makes it quicker and simpler. But I have used the manual mode when cloning to different sized drives and it works quite well also. Just takes a little more time and effort.