I'm a big fan of side-by-side comparisons. You know, actually listing out the specification and components that are on all motherboards, and then comparing the different product's specs against each other.
For instance, some motherboards have 2 network interface ports (NICs). Do I need 2? No. So I will eliminate all those boards from consideration.
Some boards have newer sound chips, some have more SATA connections, etc. You might give those boards extra 'stars' for greater consideration. That way you can see if you can get more bang for the buck.
Oh, yeah, and then there is the price........