Help with mouse problems

Yeah; but this problem seems to have co-existed with Windows for over 10 years and still no clear solution, but hundreds of possibilities...
 

My Computer

Computer Manufacturer/Model Number
custom
OS
Windows 7 Home Premium 64 bit
CPU
3.40 gigahertz Intel Core i7-2600K
Motherboard
Gigabyte
Memory
2 TB
Monitor(s) Displays
Samsung SyncMaster 275T 27 inch
Hard Drives
2x 120GB AData SSDs
PSU
NotSure
Cooling
air
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