Incase some of you are not aware Microsoft have a recommended list files/folders that should be excluded from On-Access Anti Virus scanning.
You can find the article here: Virus scanning recommendations for computers that are running Windows Server 2008 R2, Windows Server 2008, Windows Server 2003, Windows 2000, Windows XP, Windows Vista, or Windows 7
Here's their recommendations for Windows 2000, XP, Vista, 7, Server 2003 and Server 2008 and 2008 R2:
Microsoft Windows Update or Automatic Update related files
Group Policy related files

You can find the article here: Virus scanning recommendations for computers that are running Windows Server 2008 R2, Windows Server 2008, Windows Server 2003, Windows 2000, Windows XP, Windows Vista, or Windows 7
Here's their recommendations for Windows 2000, XP, Vista, 7, Server 2003 and Server 2008 and 2008 R2:
Microsoft Windows Update or Automatic Update related files
- The Windows Update or Automatic Update database file. This file is located in the following folder: %windir%\SoftwareDistribution\Datastore
Exclude the Datastore.edb file. - The transaction log files. These files are located in the following folder:%windir%\SoftwareDistribution\Datastore\Logs
Exclude the following files:- Edb*.log
Note The wildcard character indicates that there may be several files. - Res1.log. The file is named Edbres00001.jrs for Windows Vista, Windows 7, Windows Server 2008, and Windows Server 2008 R2.
- Res2.log. The file is named Edbres00002.jrs for Windows Vista, Windows 7, Windows Server 2008, and Windows Server 2008 R2.
- Edb.chk
- Tmp.edb
- The following files in the %windir%\security path should be added to the exclusions list:
- *.edb
- *.sdb
- *.log
- *.chk
- Edb.chk
- Edb.log
- *.log
- Security.sdb in the <drive>:\windows\security\database folder
- Edb*.log
Group Policy related files
- Group Policy user registry information. These files are located in the following folder: %allusersprofile%\
Exclude the following file: NTUser.pol - Group Policy client settings file. These files are located in the following folder:%Systemroot%\system32\GroupPolicy\
Exclude the following file: registry.pol
My Computer
- OS
- Windows 7 Ultimate x64
- CPU
- 2x AMD FX-74 @ 3GHz
- Motherboard
- ASUS L1N64-SLI WS
- Memory
- 4GB
- Graphics Card(s)
- 2x BFG 8800GTX OC
- Sound Card
- Creative X-Fi Fatal1ty
- Monitor(s) Displays
- HP L2045w
- Hard Drives
- 2x Samsung Spinpoint
- PSU
- Enermax 1000W
- Case
- Armor Extreme ATX
- Cooling
- Air