I echo Bill's post.
Windows is a closed source system. Developers of registry cleaners do not have the core code of Win 7 and are not working on definitive information, but rather empirical knowledge. Automatic cleaners will usually have to do some guesswork. Modifying registry keys incorrectly can cause Windows instability, or make Windows unbootable. No registry cleaner is completely safe and the potential is ever present to cause more problems than they claim to fix.
My advice for the average computer user is DO NOT using a registry cleaner. If you do not have knowledge of the registry, then you are far better off leaving it alone, and definitely not placing blind trust in a program to do the job for you. Registry cleaners cannot distinguish between good and bad. If you run a registry cleaner, it will delete all those keys which are obsolete and sitting idle; but in reality, those keys may well be needed by some programs or windows at a later time.
Registry defragger programs are a myth, too. They might trim the registry size by 8-12MB; but will not improve operating system performance. In fact, your programs’ performance will decrease.
[FONT="]Win 7 does not need a registry cleaner. Forget all the "wisdom" you learned about XP. Win 7 is not XP and does not manage the registry the same as XP.
Win 7 is much more efficient at managing the registry than previous Windows versions. If you are very knowledgeable of the registry, you can use Ccleaner to delete keys left over when uninstalling programs. However, these few keys will not make 1 millisecond's difference in performance. If you run Ccleaner or any other registry cleaner and do not know precisely what you are doing, you will have problems down the road. There are no gains to be had from using a registry cleaner and the risk is great[/FONT]