Systemwide stuttering after 2-3+ days of uptime

Iamazn

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I rarely turn my computer off. After two or three days of continuous uptime, my computer starts stuttering. Every few seconds, mouse and keyboard input will pause for a brief moment. It's fixed with a reboot, but I really don't like restarting my computer. How can I fix the stuttering without rebooting?
 

My Computer My Computer

At a glance

Windows 7 Ultimate x64i7 3770k16GBGTX 680
Computer type
PC/Desktop
OS
Windows 7 Ultimate x64
CPU
i7 3770k
Memory
16GB
Graphics Card(s)
GTX 680
Screen Resolution
5760x1080
I rarely turn my computer off. After two or three days of continuous uptime, my computer starts stuttering. Every few seconds, mouse and keyboard input will pause for a brief moment. It's fixed with a reboot, but I really don't like restarting my computer. How can I fix the stuttering without rebooting?

Do you have your monitor set so that it goes dark after a certain about of time with no keystrokes (20 minutes for me)?
 

My Computer My Computer

At a glance

Windows 7 Home Premium 32-Bit - Build 7600 SP1Intel Core i3-2120 3.30GhzKingston 4 GB DDR3 1333 mhzAMD Radeon HD6670
Computer type
PC/Desktop
Computer Manufacturer/Model Number
Custom Build
OS
Windows 7 Home Premium 32-Bit - Build 7600 SP1
CPU
Intel Core i3-2120 3.30Ghz
Motherboard
Asus P8Z68-V LX Intel Z68 Socket H2 ATX
Memory
Kingston 4 GB DDR3 1333 mhz
Graphics Card(s)
AMD Radeon HD6670
Sound Card
Sound Blaster Audigy SE 24-Bit
Monitor(s) Displays
Asus VE228
Screen Resolution
1440 X 900
Hard Drives
OCZ Vertex 3 120 GB Sata 3 SSD ==
Kingston SH103/S3 120 G Hyper X 120 GB SSD ==
Western Digital 500 GB Caviar Green 7200 RPM ==
PSU
Corsair CX600M == 600 Watt
Case
NZXT Apollo - Silver with Clear Side Panel
Cooling
Three 120 mm Fans
Keyboard
Microsoft Natural 4000
Mouse
Microsoft Custom Optical 3000
Internet Speed
AT&T Fiber Optic Wireless Network
Antivirus
Microsoft Security Essentials
Browser
Chrome
Other Info
120 mm Blue LED Fan -- Three Blue LED Lazer Light Sticks
I rarely turn my computer off. After two or three days of continuous uptime, my computer starts stuttering. Every few seconds, mouse and keyboard input will pause for a brief moment. It's fixed with a reboot, but I really don't like restarting my computer. How can I fix the stuttering without rebooting?

Do you have your monitor set so that it goes dark after a certain about of time with no keystrokes (20 minutes for me)?
Yes, I believe it is set to 5 minutes.
 

My Computer My Computer

At a glance

Windows 7 Ultimate x64i7 3770k16GBGTX 680
Computer type
PC/Desktop
OS
Windows 7 Ultimate x64
CPU
i7 3770k
Memory
16GB
Graphics Card(s)
GTX 680
Screen Resolution
5760x1080
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