thumbs.db

[Frank1]

Do I really need all of those thumbs.db files? .

 

[Mashed1316]

Well, here's something you could read

Windows thumbnail cache - Wikipedia, the free encyclopedia

I really don't like them but they're generated automatically, so it doesn't matter if you delete them, they will reappear

 

[NoN]

You can open cmd prompt as adminitrator in the drive you want them to be cleaned (just change the letter of the drive, type:
C:\>del /s thumbs.db

It will scan the all drive and delete those .db

Or use the native Windows 7 settings:
How To Delete Thumbs.db in Windows 7