Over 90% of the time, yes. Probably over 95%. But some old applications won't even install on a 64-bit system. If your software is all from the last 8 or 10 years, it may all work fine.
If you had 2 systems that had 3 GB of RAM and were otherwise identical, you probably wouldn't know which was 32-bit and which was 64-bit. Even with larger amounts of RAM, you might not be able to tell if that RAM wasn't in use.
Sooner or later you will be forced into 64-bit, so you may as well use it if your hardware accepts it. I don't know that I would go through a week of configuration to do it---probably just wait until I had to do a clean install anyway.
My Computer
At a glance
Windows 7 Home Premium SP1, 64-bitIntel Skylake i5-6600K, not overclocked8 GB HyperX DDR4-2666 (2 x 4 GB)none; graphics are integrated on CPU
Computer type
PC/Desktop
Computer Manufacturer/Model Number
Ignatz Special; 4 speed manual gearbox; factory air conditioning; one of one
OS
Windows 7 Home Premium SP1, 64-bit
CPU
Intel Skylake i5-6600K, not overclocked
Motherboard
AsRock Z170M Extreme 4, micro ATX
Memory
8 GB HyperX DDR4-2666 (2 x 4 GB)
Graphics Card(s)
none; graphics are integrated on CPU
Sound Card
onboard: Realtek ALC1150; external: USB Behringer UF0-202
Monitor(s) Displays
Dell S2340M 23 inch IPS
Screen Resolution
1600 x 900
Hard Drives
System: Crucial MX100 series SSD, 128 GB;
Data: Samsung Spinpoint 103SJ, 1 TB;
Backup: WD Caviar Green WD30EZRX-00D8PB0, 3 TB
Microsoft Security Essentials and Malwarebytes Premium
Browser
Pale Moon
Other Info
All fans PWM; speeds at idle: CPU circa 500 rpm; intake circa 600 rpm; exhaust circa 600 rpm; CPU temps 27 idle and 47 C load in a warm room (27 C/81 F) when running Intel Extreme Tuning Utility stress test.
