Hi.. i have my XBOX 360 placed vertically right beside my PC as there's not much space to place it horizontal there as well as im using PC ans 360 with the same LCD Monitor. Personally i also like it in Vertical position coz i have easy access to place the disc in + attaching the cables and inserting USB in it. Also in Summer season the ceiling fan spins and throw the air on the floor which travels nicely on the both sides of the console over the floor rather than getting hot on the bottom when placed horizontal. Now lets jump on the real question!!! last year my 360's 60GB HDD died and i recently bought a used 20GB HDD from a guy. The guy had painted his console and the HDD case so when i bought the HDD i decided to change the HDD case with the one i have from 60GB. I replaced the cases successfully but during replacing i noticed that Microsoft put the HDD upside down in the case/enclosure. So it means im using my 360 vertically and the HDD case is on the top which is holding the HDD in upside down position so is it normal to use it in that postion? 
My Computer
At a glance
Windows 10 ProCore i5 9600KCorsair Vengeance Pro 2x 8GB (16GB) 3200MHz DDR4MSI GTX 1070 Gaming X 8GB
- Computer type
- PC/Desktop
- Computer Manufacturer/Model Number
- Self Built
- OS
- Windows 10 Pro
- CPU
- Core i5 9600K
- Motherboard
- ASUS ROG Strix Z390-F Gaming
- Memory
- Corsair Vengeance Pro 2x 8GB (16GB) 3200MHz DDR4
- Graphics Card(s)
- MSI GTX 1070 Gaming X 8GB
- Sound Card
- ASRock A-Style Purity Sound
- Monitor(s) Displays
- ASUS VX239H IPS
- Screen Resolution
- 1920x1080
- Hard Drives
- XPG SPECTRIX S40G 2566GB M.2 NVMe | Patriot P210 512GB SSD | Seagate BarraCuda 4TB 5400RPM
- PSU
- Thermaltake Smart 600w RGB 80Plus
- Case
- NZXT H500 with 3x Corsair HD120 RGB w/Node Pro
- Cooling
- Cryorig H7
- Keyboard
- Corsair K70 RapidFire RGB (Cherry MX Speed)
- Mouse
- Logitech G402 Hyperion Fury
- Internet Speed
- 20MB Cable Broadband
- Browser
- Chrome
- Other Info
- Corsair MM300 Extended Anti-Fray Mouse Pad | Edifier C2 2.1ch Sound System | XBOX One S Controller | XBOX 360 Wireless Controller for Windows | APC SUA1000i Smart-UPS | PS4 Slim 500GB [Region 1 - USA]