xchase,
Actually, you have enough free space on your E (~385 GB) to hold a backup from you C.
Your Disk2 also has one unused partition, albeit less than 100 GB, but still not to be laughed at.
You also have a "raw" formatted partition on that Disk2.
What do you have there?
With a bootable Partition Wizard CD and maybe even only using Disk Managment you could do some shuffling on that drive.
Using some normal "tricks" you can probably get your C down to where you have at least 20% free.
As things presently sit, you might consider going to your local electronics store and picking up an external USB drive. I had one chap tell me that he picked up a 500GB for $50 which is a very good price. My biggest external usb drive is 300GB,
With such a full C drive, you must have many videos stored on the drive. I can't even use 50 GB for Win 7, documents, pics, movies, etc.
Let us know your plans for your Disk2 and whether you want to consider putting your videos onto an external usb.
When we have a good idea of your plans and needs, we can make better recommendations.