Do you have any idea what this problem is?

[supvic]

I've only seen it happen with 3 programs... The interface disappears but everything is still clickable...

 

[ICIT2LOL]

Hello and welcome supvic mate some system specs would be good - very hard to help if we do not know what you have in the way of a setup. http://www.sevenforums.com/tutorials/180324-system-info-see-your-system-specs.html

But for starters mate run these anyway
http://www.sevenforums.com/tutorials/1538-sfc-scannow-command-system-file-checker.html
http://www.sevenforums.com/tutorials/433-disk-check.html - use Option 2 and if needed the /f and /r switches

if no go then these

SUPERAntiSpyware | Remove Malware | Remove Spyware - AntiMalware, AntiSpyware, AntiAdware!
https://www.malwarebytes.org/antimalware/ when downloading and installing watch out for the tick box for the trial version untick it if you do not want to trial it (see below)
AdwCleaner Download
(NB if you have Kaspersky installed it may rave on about the download – ignore it or disable it for the duration of the download/scan)
For any unwanted addon programs that come packaged with other softwares use this
Unchecky - Keeps your checkboxes clear (Unchecky is not absolutely necessary but will stop unwanted add ons and trials)