I do, I have used vipre and upgraded to Vipre premium on all of my home machines. I bought the "all you can eat" version and it works well on my Windows 7 and XP machines. I even run it on my windows server 2008 (x32) version. I did turn off the option to check files when opened or copied as I believe that slows things down.
It seems to be very non intrusive and just sits there watching what I do. I have never had a virus or trojan, so far.
I am a small business consultant also, and have all of my clients with Vipre.
It is reasonable in price, especially for the "all you can eat" version for home use.
I don't have any financial interest just a satisfied customer.
Rich