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Fallout 3 on Windows 7 w/quad core
Vista SP2 with a dual core worked fine. After upgrading to a quad core and Windows 7, I was lucky if I could play more than 5 minutes without a freeze.
A fine gentleman named Nicholas Head posted this solution on his blog. Along with several others, I can confirm this fix works! (YRMV)
Fallout 3: Video/Display Freezes, sound keeps going
by Nicholas Head 7. February 2009 00:35
Ever since Bethesda came out with the 1.1 patch for Fallout 3, I couldn’t play the game anymore. Once I got into the game and started wandering around, I’d randomly “freeze” up… the video would stop updating, but the sounds/music would still play. Keyboard clicks and mouse clicks did nothing, requiring me to ctrl+alt+del and kill the task manually.
It looked like I was SOL until the next patch, but I found some help online:The game engine has some issues with processors that have more than 2 cores. You can force the game to only use two of them and it will stop the freezing. I haven't had it freeze once since I did this several days ago.Surprisingly, this worked like I charm. I do indeed have a quad core processor, so it sounds like this was the culprit. Why 1.1 broke the game for me.. I have no idea. It sounds like Bethesda needs to do some better testing on multi-core processors.
Open up the fallout.ini file in: My Documents\My Games\Fallout3
Find the line:
bUseThreadedAI=0
change it to:
bUseThreadedAI=1
Add another line after it and insert:
iNumHWThreads=2
This will limit the game to 2 cores and prevent the engine bug from causing the game to freeze.
Hopefully this helps someone else out there!

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When my buddy sent me this OS I had to upgrade my hardware so it would take and I thought that might have something to do with the problems I'm having. After purchacing the mobo the chart showed that my 7900GT was not compatible but all my EA games play without a hitch.