Solved Huge amount of mystery space taken up on Hard Drive

PROBLEM SOLVED!

Firstly I discovering that the problem in hand was located at:

C:\Windows\SysWOW64\config\systemprofile\AppData\Local\Microsoft\Windows\Temporary Internet Files\Content.IE5\

I found this by using WizTree.
Available here: Antibody Software - WizTree finds the files and folders using the most disk space on your hard drive)

I was unable to access this location via explorer, it would always freeze up. So I am using CCleaner to clear out this folder "Content.IE5". In CCleaner I added a custom folder to clean by navigating to:
Options > Include > Add ... then pasting that location into the 'Drive or Folder' area.

CCleaner is available here: https://www.piriform.com/ccleaner/download ...(I downloaded the free version)

Now CCleaner is slooooowly clearing out this folder and I am slooowly getting my space back. As I am writing this, it has cleaned about 10GB in 1-2 hours. There is approx. 500GB to clean. It is going to take a while, but at least I've found a solution to the problem. Maybe if you find a more convenient way of deleting this folder you can let me know. But for now this is the way I am doing it.

Thanks to everyone who helped out :)

EDIT: Thought I'd post this edit to let you all know how long it took to clear. For memory, I think it took around 5-7 days to clear through it all. Pretty sure there was a solid 400GB or so of files (junk) in the specified folder above. Had to restart a few times (CCleaner started from where it was up to before restart).
 
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My Computer My Computer

At a glance

Windows 7 Home Premium, 64 Bit8GB
Computer type
Laptop
Computer Manufacturer/Model Number
HP
OS
Windows 7 Home Premium, 64 Bit
Memory
8GB
Antivirus
Norton 360
Good going and well done. Thanks for sharing all the info especially adding a custom folder to clean in CCleaner.
 

My Computer My Computer

At a glance

Windows 7 Home Premium 32 bit
OS
Windows 7 Home Premium 32 bit
Hmm didn't see this thread until today an would have suggested WizTree - shame is I should have found it before I wrecked the drive in my other laptop and perhaps I would not have done.

So it is on all my machines now and the GUI is much easier to use than WinDirStat.
 

My Computer My Computer

At a glance

Desk1 7 Home Prem / Desk2 10 Pro / Main lap A...Desk1 i5 3750K / Laptop i7 GTX 860M / Desk2 i...Desk1 8GB (1866) / Desk2 16GB (1333) / Laptop...Desk 1& 2NVidia GTX 650 & Laptops on board Intel
Computer type
PC/Desktop
Computer Manufacturer/Model Number
Own build (new) Desk1 / Asus ROG Win 7 / Desk2 1st build
OS
Desk1 7 Home Prem / Desk2 10 Pro / Main lap Asus ROG 10 Pro 2 laptop Toshiba 7 Pro Asus P2520 7 & 10
CPU
Desk1 i5 3750K / Laptop i7 GTX 860M / Desk2 i5 2500
Motherboard
Desk1 Asus P877-V / Desk2 Gigabyte H67 UD3H / Laptop ?
Memory
Desk1 8GB (1866) / Desk2 16GB (1333) / Laptop 8Gb DDR3
Graphics Card(s)
Desk 1& 2NVidia GTX 650 & Laptops on board Intel
Sound Card
Desk 1 & 2 -XONAR DG Realtek High Def audio Laptop
Monitor(s) Displays
Desk 1 Benq HD 2450 / Desk2 Philips 24" / Laptop 17.5"
Screen Resolution
1920x1080 D1 & D2 & Laptop 1
Hard Drives
Desk1 Samsung 120GB 830 SSD
Asus ROG 256GB 850 Pro SSD
Desk2 Samsung 840 256 SSD
Toshiba 120GB EVO
PSU
Desk 1 Corsair HX 1050/ Laptop ? / Desk 2 Corsair HX 650
Case
Desk 1 Cooler HAF XM ? Toshiba laptop / Desk2 Coolermaster
Cooling
Fans on all Desk1 -2 Desk2 - all Coolermasters 5 Laptop ?
Keyboard
Desk 1 MS Sidewinder X6 Desk 2 MS Sidewinder X 4
Mouse
Desk 1&2 - Gigabyte MS 900 gamer - laptop - Logitec wireless
Internet Speed
ADSL2+
Other Info
One other Desktop (tester) and spare Toshba laptop both with SSD's
Running Kaspersky 2016 ISS on all machines config'd identically
Logitec audio stereo systems on each machine (x3)
Canon MG5250MFC
Router/modem TP-Link running WPA2SK
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