Windows folder is 365 GB

CCleaner's reg cleaner is what I refer to as a non-invasive reg cleaner, it is the only one I fully trust. As for any performance increase I never noticed but because I run it here and there it never has much to clean.

By non-invasive I mean it is not as thorough as some others giving it the best chance not to create errors.

For example I just downloaded a different reg cleaner and straight after running CCleaner's it found an additional 2813 problems. I'm almost tempted to create an image of my system and then clean those entries to see if I get any performance increase.
 

My Computer My Computer

At a glance

Windows 7 Ultimate x64Intel Pentium Dual Core E5200 2.5GHz (3.77GHz...Corsair 4GB DDR2 (4x1GB CM2X1024-6400C4)Palit GeForce GTS 250 (1024MB)
Computer Manufacturer/Model Number
Self built
OS
Windows 7 Ultimate x64
CPU
Intel Pentium Dual Core E5200 2.5GHz (3.77GHz OC)
Motherboard
Asus P5Q-E
Memory
Corsair 4GB DDR2 (4x1GB CM2X1024-6400C4)
Graphics Card(s)
Palit GeForce GTS 250 (1024MB)
Sound Card
On Board (ADI AD2000B 8ch HD)
Monitor(s) Displays
Samsung 32in LCD TV
Screen Resolution
1360x768
Hard Drives
2 x 1TB Samsung 103SJ (Raid0)
2 x External 500GB Samsung 502IJ (NexStar 3 HD Enclosures)
PSU
550W Antec Neo HE 550
Case
Antec P180
Cooling
Xigmatex Red Scorpion CPU Cooler. 3x120mm Fans
Keyboard
Logitech MX5000 Laser (Combo)
Mouse
Logitech MX5000 Laser (Combo)
Internet Speed
ADSL2+ (avg 10 Mbps Down, 0.80 Mbps up)
Other Info
Gigabyte GN-WP01GS 54g Wireless Lan Card
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