Disabled is the default option.
And btw, I've heard that the setting doesn't have any effect in Win 7, that it only was used in pre-vista 32-bits. And that the setting is left in registry just for compatibility reasons.
Anyhow, LargeSystemCache is meant for server use more, hence the name, then background processes gets a bigger attention from the CPU than running programs. LargeSystemCache is also helpful in a network where large over 1GB files are moved around every day basis.
Unless your running a file server which needs a large system cache - with the expense of front running brograms, leave the setting alone.