What I do is start it, press the power button for a hard shut-down and repeat till I get "your windows didn't shut down properly. press f8 for advanced start options".
When you see that screen, boot into safe mode. When in safe mode, AS SOON as you see your desktop, hit alt-ctrl-del before the virus has a chance to load. Then kill the process as it comes up.
Then with a thumb drive handy, install Malwarebytes. That will further cripple it. Follow that with Spybot and finally windows defender. I include windows defender because I think it restores permissions that are set wrong. Follow this with a virus scan.
Then when you're done, go through your system settings and make sure everything works. I can almost guarantee you that a few things are going to be hosed. So, as soon as the virus is off, create a new account, move everything over, log into your new account and delete all the other accounts.