computer unable to open files after a while, ok in safe mode

prerunner97

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My desktop after a while will not open any programs or files. I would say after 30 min to an hour. I have to reset the computer manually and the whole issue happens again. This doesn't appear to happen in safe mode though. I've used multiple virus programs to remove them but the issue still remains. I run windows 7 32 bit. Any help would be appreciated. Thank you very much for taking the time to read this.
 

My Computer My Computer

At a glance

windows 7 32 bitAMD Athlon II x4 620 @ 2600MHz4096 MB (2x 2048 DDR3-SDRAM)ATI Radeon HD 4300/4500 Series
Computer type
PC/Desktop
Computer Manufacturer/Model Number
custom
OS
windows 7 32 bit
CPU
AMD Athlon II x4 620 @ 2600MHz
Motherboard
Asus M4A785TD-M EVO
Memory
4096 MB (2x 2048 DDR3-SDRAM)
Graphics Card(s)
ATI Radeon HD 4300/4500 Series
Sound Card
ASUSTeK Computer SB600 High Definition Audio Controller
Monitor(s) Displays
Acer P235H - 23 Inches
Hard Drives
Western Digital WD10001FALS-00J7B1 ATA Device (1000GB) X 2
Hello prerunner97,

You could try a Clean Startup and see if you can determine a startup program you have that is causing the issue.
http://www.sevenforums.com/tutorial...ation-conflicts-performing-clean-startup.html

You stated "I've used multiple virus programs to remove them but the issue still remains."
Does that mean you found malware, and removed what was found?
If so, maybe there are still some malware problems?
I'm no Malware expert, but there is a SF System Security forum where you could add a thread explaining your issue, and experts there might be able to help you.
 

My Computer My Computer

At a glance

Multi-Boot W7_Pro_x64 W8.1_Pro_x64 W10_Pro_x6...AMD Athlon II x4 6206GB GSkill DDR2 800AMD 4670 GPU + AMD 4200 IGP
Computer type
PC/Desktop
Computer Manufacturer/Model Number
home built
OS
Multi-Boot W7_Pro_x64 W8.1_Pro_x64 W10_Pro_x64 +Linux_VMs +Chromium_VM
CPU
AMD Athlon II x4 620
Motherboard
Gigabyte GA-MA785G-UD3H
Memory
6GB GSkill DDR2 800
Graphics Card(s)
AMD 4670 GPU + AMD 4200 IGP
Sound Card
on board Realtek ALC889A
Monitor(s) Displays
RCA 40" LCD TV, Insignia 32" LCD TV, HP 15" LCD monitor
Screen Resolution
1680 x 1050
Hard Drives
OCZ Vertex 3 120GB,
Samsung F3 1TB (3),
Several others - WD, Seagate, Hitachi, ...
PSU
Corsair 500 W
Case
Rosewill mid tower
Cooling
CM 90mm rifle
Keyboard
Gyration wireless, Logitech wireless, Dell USB wired
Mouse
Gyration wireless, Logitech wireless, V7 USB wired
Internet Speed
Spectrum - 100Mbps D / 10Mbps U
Antivirus
Avast, MBAM3, EMET, WinPatrol
Browser
Pale Moon, Firefox, IE
Other Info
2 multi-boot PC's
Mainly HTPC/Office/Gen purpose (no gaming).
Trendnet USB KVM.
LG DVD burner/Blue Ray Player.
Tray system for removable SATA backup drives.

Not currently OCd, under-volted.
I use Hybrid sleep, rarely re-boot or shutdown.

Hauppauge HD-PVR, Avermedia PCIe TV Tuner, Hauppauge PCI TV Tuner.
Also, as you stated "I've used multiple virus programs to remove them but the issue still remains."

Are you running more than one real-time anti-virus program at the same time?
If you are, that can cause problems.
What real time anti-virus program(s), and real-time anti-malware program(s) are you using?

Using on-demand scanners should not be an issue...
 

My Computer My Computer

At a glance

Multi-Boot W7_Pro_x64 W8.1_Pro_x64 W10_Pro_x6...AMD Athlon II x4 6206GB GSkill DDR2 800AMD 4670 GPU + AMD 4200 IGP
Computer type
PC/Desktop
Computer Manufacturer/Model Number
home built
OS
Multi-Boot W7_Pro_x64 W8.1_Pro_x64 W10_Pro_x64 +Linux_VMs +Chromium_VM
CPU
AMD Athlon II x4 620
Motherboard
Gigabyte GA-MA785G-UD3H
Memory
6GB GSkill DDR2 800
Graphics Card(s)
AMD 4670 GPU + AMD 4200 IGP
Sound Card
on board Realtek ALC889A
Monitor(s) Displays
RCA 40" LCD TV, Insignia 32" LCD TV, HP 15" LCD monitor
Screen Resolution
1680 x 1050
Hard Drives
OCZ Vertex 3 120GB,
Samsung F3 1TB (3),
Several others - WD, Seagate, Hitachi, ...
PSU
Corsair 500 W
Case
Rosewill mid tower
Cooling
CM 90mm rifle
Keyboard
Gyration wireless, Logitech wireless, Dell USB wired
Mouse
Gyration wireless, Logitech wireless, V7 USB wired
Internet Speed
Spectrum - 100Mbps D / 10Mbps U
Antivirus
Avast, MBAM3, EMET, WinPatrol
Browser
Pale Moon, Firefox, IE
Other Info
2 multi-boot PC's
Mainly HTPC/Office/Gen purpose (no gaming).
Trendnet USB KVM.
LG DVD burner/Blue Ray Player.
Tray system for removable SATA backup drives.

Not currently OCd, under-volted.
I use Hybrid sleep, rarely re-boot or shutdown.

Hauppauge HD-PVR, Avermedia PCIe TV Tuner, Hauppauge PCI TV Tuner.
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