Is your E: drive configured to run defrag on a schedule? In that case, defrag would run in the background and keep the drive unfragmented without your intervention.

I downloaded this defragger and used it, and optimized. I think I see an improvement in performance. I use Ccleaner for cleaning only, and now I will use this defragger for defragging instead of Windows defragger, but..... I don't recommend using ANYTHING other than Windows 7's built in systems for messing with the registry. DON'T MESS WITH THE REGISTRY UNLESS YOU ARE A PRO, AND YOU HAVE A KNOWN PROBLEM AND A KNOWN SOLUTION FOR THAT SPECIFIC PROBLEM! This is the voice of experience talking here.