External Hard Drive keeps on showing Autoplay prompt

If you're comfortable backing up and modifying registry -
In regedit look at:
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Policies\Explorer
If the Explorer key isn't there, look here instead:

HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Policies\Explorer
(If the Explorer key isn't there, create it)

In the right pane create the dword "NoDriveTypeAutoRun"
Default value is 91 which is supposed to stop autorun on unknown and network drives, which is default behaviour.
A value of 99 should stop autorun on fixed drives as well.
Or a value of 8 stops autotun for fixed drives only.
In your case, I would try 99, which would cover most of the ways your Windows could be seeing that drive.

Well, that is disabling Autoplay at all, right? I am comfortable with Autoplay turned ON, it's just that I want it to run normal just like before where a pop-up doesn't show upon startup due to the external HDD.
 

My Computer My Computer

At a glance

Windows 7 Ultimate x6i5 2670QM2x4GB RAM Kingston HyperX Memory DDR3 1600 MH...Nvidia GeForce GTX 560M
Computer Manufacturer/Model Number
Sager NP8130
OS
Windows 7 Ultimate x6
CPU
i5 2670QM
Memory
2x4GB RAM Kingston HyperX Memory DDR3 1600 MHz Sticks
Graphics Card(s)
Nvidia GeForce GTX 560M
Sound Card
Realtek HD Audio (Built-in)
Screen Resolution
1920x1080
Hard Drives
128GB Crucial M4 SSD
500GB Seagate 7200RPM HDD
Internet Speed
12Mbps down/4Mbps up
Well, that is disabling Autoplay at all, right? I am comfortable with Autoplay turned ON, it's just that I want it to run normal just like before where a pop-up doesn't show upon startup due to the external HDD.
No, Autoplay should still work as normal for your USB sticks, CD/DVD, Audio/Video files etc., depending how you set it up for yourself. Don't be put off by the name "NoDriveTypeAutoRun" - it's just the place where you can set policies according to the value you use.
Try a value of 99 and see - you can undo it if no joy. Btw, I've tried all the settings I gave you and they behaved as expected.
 

My Computer My Computer

At a glance

Windows 7
OS
Windows 7
Ok then. Btw, I also tried enabling USB legacy support and the same result :( I hate why it's happening.

All of my drives have a GPT partition, is that related to this issue?
 

My Computer My Computer

At a glance

Windows 7 Ultimate x6i5 2670QM2x4GB RAM Kingston HyperX Memory DDR3 1600 MH...Nvidia GeForce GTX 560M
Computer Manufacturer/Model Number
Sager NP8130
OS
Windows 7 Ultimate x6
CPU
i5 2670QM
Memory
2x4GB RAM Kingston HyperX Memory DDR3 1600 MHz Sticks
Graphics Card(s)
Nvidia GeForce GTX 560M
Sound Card
Realtek HD Audio (Built-in)
Screen Resolution
1920x1080
Hard Drives
128GB Crucial M4 SSD
500GB Seagate 7200RPM HDD
Internet Speed
12Mbps down/4Mbps up

My Computer My Computer

At a glance

Win 7 Pro 64-bitIntel i5 2.4 Ghz8GB DDR3Intel HD 3000
Computer type
Laptop
Computer Manufacturer/Model Number
Sony Vaio VPCEB47GM Laptop
OS
Win 7 Pro 64-bit
CPU
Intel i5 2.4 Ghz
Memory
8GB DDR3
Graphics Card(s)
Intel HD 3000
Sound Card
IDT High Definition
Monitor(s) Displays
15.6 WGXA Anti-Glare LED
Screen Resolution
1280x800
Hard Drives
640Gb 7200rpm
Antivirus
MSE
Browser
Opera (primary) with IE9 backup
I had the same irritating (and potentially data-damaging) issue of the portable external HDD (IOMEGA Prestige 1TB Portable Superspeed USB3.0 HDD) constantly disconnecting & reconnecting (and thus popping the Windows Autoplay prompt) on my home notebook (Dell XPS L501X).

Interestingly, this issue happened only when the portable HDD was connected to any of the USB3.0 ports on the laptop, it didn't occur when connected to the USB2.0+eSATA combo port, so I understood it is a power cycling issue.

All USB3.0 ports are powered ports, and most of the Windows installations have a the "balanced" power-saving mode ON by default (especially for notebooks/netbooks). Windows tries to turn off the USB3.0 devices to save power. Unfortunately, this happens even when the device has been connected just a few seconds ago.

If you are not keen on using a USB3.0 device on a USB2.0 port, you can change the power plan in Windows, but it is not the ideal solution, see this thread for the solution that should work:

http://www.sevenforums.com/hardware-devices/128715-external-hard-drive-constant-auto-play.html
 

My Computer My Computer

At a glance

Windows 7 Home Premium 64-bit, Windows 7 Star...
OS
Windows 7 Home Premium 64-bit, Windows 7 Starter 32-bit
USB 3 is buggy - it also interferes with 2.4Ghz wireless devices working properly.
 

My Computer My Computer

At a glance

Windows 7 Home Premium x64i7 5930KCorsair Dominator, DDR4 16GBEVGA GTX 980 SLI
OS
Windows 7 Home Premium x64
CPU
i7 5930K
Motherboard
Asus X99-A
Memory
Corsair Dominator, DDR4 16GB
Graphics Card(s)
EVGA GTX 980 SLI
Sound Card
Onboard Realtek HD
Monitor(s) Displays
Dell U3011
Screen Resolution
2560x1600 (16:10, as god intended)
Hard Drives
Samsung 850 EVO 1TB SSD (Boot OS)
2 x Hitachi 7K3000 2TB (Storage)
PSU
Seasonic 1250W
Case
Corsair 900D
Cooling
Corsair H110 280
Keyboard
Logitech Wireless Illuminated keyboard K800
Mouse
Loigitech M950 Performance
Internet Speed
ADSL 2+
Antivirus
MS SE
Browser
Chrome
kevindd992002 HDD Autoplay Popups

Go to Run
Then type "msconfig"
Don't copy the quote symbols
Open the tab "Services"
Don't hide Microsoft Services
Disable "Shell Hardware Detection" (uncheck the box at left)
Disable "WinHTTP Web Proxy Auto-Discovery Service" (uncheck the box at left)
Reboot

This should help
 

My Computer My Computer

At a glance

WindowsIntel i5 4670 3.4 GHz HaswellRAM 16GB Corsair Vengeance Pro (2x8) DDR 3Nvidia GeForce GT-610
Computer type
PC/Desktop
Computer Manufacturer/Model Number
custom build
OS
Windows
CPU
Intel i5 4670 3.4 GHz Haswell
Motherboard
Gigabyte H87M-D3H (Socket 0)
Memory
RAM 16GB Corsair Vengeance Pro (2x8) DDR 3
Graphics Card(s)
Nvidia GeForce GT-610
Sound Card
NVIDIA HD-Realtek HD-NVIDIA Virtual (WDM)-Intel Display
Monitor(s) Displays
Generic PnP Samsung / 46'' Samsung Smart TV
Screen Resolution
1366 x 768
Hard Drives
931 GB Western Digital SCSI Disk Device (SATA)
1862 GB Western Digital WD My Passport 3.0 USB Device (SATA)
931 GB Toshiba External USB 3.0 (SATA)
1862 GB Western Digital WD Elements 3.0 USB Device (SATA)
Keyboard
HID Keyboard Device
Mouse
Microsoft PS/2
Internet Speed
Down 40Mbps Up 2Mbps
Antivirus
Bitdefender TS 2015-Malwarebytes Premium-Combofix-Spybot-Oth
Browser
Chrome, Firefox, Tor and Explorer installed - Use only Chrom
Other Info
http://speccy.piriform.com/results/ssUhOLoEtnTDiiYPNg7nXgl
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