I'm a firm believer in KISS (Keep It Simple, Stupid). Due to the increasing amount of data I have (imaging and cloning take too long now) and the desire to be able to access data from a backup without having to use a program to mount an image, the only thing I image anymore now is my boot SSD, which only has the OS and System Reserved partitions on it. I prefer Macrium Reflect over Win 7's imaging since I've never had MR fail me and I've read far too many accounts of people having problem with Win 7's imaging program. In fact, I've found imaging with MR to be far, far more reliable than System Restore so I shut the latter off.
Since the only thing I image anymore is the entire boot drive (the System Reserved is only 100 MB—big deal—so it's not a problem to play it safe and include it with each image), I don't need to bother with setting MR up each time since it retains the previous settings. I also disable making an XML file when making an image since I have no need for it anymore.
I have a folder on my main data drive to park my images in (I used to use dated folders to keep them in until whs pointed out that one can just use Windows file system to identify the date of a file; duh!). I'm a firm believer in planned redundancy for backups but it takes between 9 and 10 minutes to make an image (I'm imaging 60GB; I have a huge hiberfil.sys file I have to keep for my UPS) so making multiple images or copying them to multiple drives was a bit time consuming (I also have MR set to automatically verify an image after it is made; it almost doubles the total time for making an image but it saved me from betting burned by a bad image once). Since I have the Pro version (four license family pack), I have Recovery from Windows boot menu available to me so having a copy on an internal drive in my computer is handy for quick restores. The folder I have the images in then gets automatically backed up when I back up the drive it's on so my image redundancy is taken of care of for me (by switching from cloning to using a file and folder syncing program, I've got my data backups refined to the point I can run two daily backups in just a few minutes—running my daily quick scans and backups can easily be done during the commercials of an hour long TV program—and I no longer need to do weekly data backups which took about six hours to do.).
I make a weekly image every week after running full scans on my antimalware programs (I'm also now doing quick scans daily). I also make an image before and after making any changes to my System, such as updating programs or the system, installing new programs, etc. I keep all my images for the current and previous calendar month, the only keep the first image of each month prior to that. I also keep the first image I made after installing Win 7 and running all the updates and another one I took after installing programs.